{"id":34029,"date":"2025-07-07T07:17:00","date_gmt":"2025-09-10T03:33:26","guid":{"rendered":"https:\/\/www.iff.com\/health-sciences\/our-products\/howaru-bl-04\/"},"modified":"2026-03-06T12:03:19","modified_gmt":"2026-03-06T17:03:19","slug":"howaru-bl-04","status":"publish","type":"our_products","link":"https:\/\/www.iff.com\/es\/health-sciences\/our-products\/howaru-bl-04\/","title":{"rendered":"HOWARU\u00ae Bl-04\u00ae\u200b"},"content":{"rendered":"<div class=\"m-block  gt gb simple-cards-v2 media-cover l-content-1\"  >\n\n\t\n\t\n\t<div class=\"m-block__container container\"\n\t\tstyle=\"; --l-block-col: 4;--l-block-gap-vertical: 30px;--l-block-gap-horizontal: 30px;\">\n\n        <div class=\"l-heading container text-left l-heading-v2\">\n\n\t        <div class=\"l-heading__content\">\n\t                <div class=\"c-heading -h2\">\n\t\t\n\t\t\n\t\t\t\t\t<h2  class=\"c-heading__title\">Bl-04\u00aeBLENDS<\/h2>\t\t\n\t\t\n\t\t    <\/div>\n\t<div class=\"c-heading__description is-wysiwyg\">\n\t\t\t\t\t<p>Learn more about IFF Health Sciences&#8217; Bl-04\u00ae blends.<\/p>\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\t<\/div>\n\n\t            \t        <\/div>\n        <\/div>\n\n\t\t<div class=\"l-rcbl l-rcbl-v1 -col4\">\n\n\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"l-rcbl__col\">\n\t\t\t\t\t\t\n<article class=\"c-block  c-block-v1 is-vertical text-left align-bottom\" style=\"--c-block-gap-vertical:25px;--c-block-gap-horizontal:25px;\">\n\n\t        <a class=\"c-block__link-full\" href=\"https:\/\/www.iff.com\/es\/health-sciences\/our-products\/howaru-gi-complete\/\" title=\"HOWARU\u00ae GI Complete\" ><\/a>\n\t\n\t        <div class=\"c-block__media\">\n\t\t\t\n\t\t\t\t<div class=\"c-image\">\n\t\t<figure class=\"c-image__media c-image__primary\">\n\t\t\t\t\t\t\t<img decoding=\"async\" class=\"c-image__src lazy\" loading=\"lazy\" src=\"https:\/\/www.iff.com\/wp-content\/uploads\/2025\/09\/d068b70b62be0324dc4c23d5d77a3a96c39d4691_cropped3-400x115.jpg\"  alt=\"d068b70b62be0324dc4c23d5d77a3a96c39d4691_cropped3\" width=\"400\" height=\"115\"\/>\t\t\t\t\t<\/figure>\n\t<\/div>\n\t        <\/div>\n\t\n    <div class=\"c-block__body\" >\n\n\t\t\n\t\t\t\t\t<h3  class=\"c-block__title\">HOWARU\u00ae GI Complete<\/h3>\t\t\n\t    <div class=\"c-block__content\">\n\t\t    <div>\n\t\t\t\t\t\t\t    \n\t\t\t\t\t\t    <\/div>\n\t    <\/div>\n\n    <\/div>\n\n<\/article>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t<div class=\"l-rcbl__col\">\n\t\t\t\t\t\t\n<article class=\"c-block  c-block-v1 is-vertical text-left align-bottom\" style=\"--c-block-gap-vertical:25px;--c-block-gap-horizontal:25px;\">\n\n\t        <a class=\"c-block__link-full\" href=\"https:\/\/www.iff.com\/es\/health-sciences\/our-products\/howaru-protect-adult\/\" title=\"HOWARU\u00ae Protect Adult\" ><\/a>\n\t\n\t        <div class=\"c-block__media\">\n\t\t\t\n\t\t\t\t<div class=\"c-image\">\n\t\t<figure class=\"c-image__media c-image__primary\">\n\t\t\t\t\t\t\t<img decoding=\"async\" class=\"c-image__src lazy\" loading=\"lazy\" src=\"https:\/\/www.iff.com\/wp-content\/uploads\/2025\/09\/IFF_HS_Our-Products_HOWARU-Protect-Adult_1-400x258.jpeg\"  alt=\"IFF_HS_Our-Products_HOWARU-Protect-Adult_1\" width=\"400\" height=\"258\"\/>\t\t\t\t\t<\/figure>\n\t<\/div>\n\t        <\/div>\n\t\n    <div class=\"c-block__body\" >\n\n\t\t\n\t\t\t\t\t<h3  class=\"c-block__title\">HOWARU\u00ae Protect Adult<\/h3>\t\t\n\t    <div class=\"c-block__content\">\n\t\t    <div>\n\t\t\t\t\t\t\t    \n\t\t\t\t\t\t    <\/div>\n\t    <\/div>\n\n    <\/div>\n\n<\/article>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t<div class=\"l-rcbl__col\">\n\t\t\t\t\t\t\n<article class=\"c-block  c-block-v1 is-vertical text-left align-bottom\" style=\"--c-block-gap-vertical:25px;--c-block-gap-horizontal:25px;\">\n\n\t        <a class=\"c-block__link-full\" href=\"https:\/\/www.iff.com\/es\/health-sciences\/our-products\/howaru-restore\/\" title=\"HOWARU\u00ae Restore\" ><\/a>\n\t\n\t        <div class=\"c-block__media\">\n\t\t\t\n\t\t\t\t<div class=\"c-image\">\n\t\t<figure class=\"c-image__media c-image__primary\">\n\t\t\t\t\t\t\t<img decoding=\"async\" class=\"c-image__src lazy\" loading=\"lazy\" src=\"https:\/\/www.iff.com\/wp-content\/uploads\/2025\/09\/Howaru-Restore-Cropped2-400x130.jpg\"  alt=\"Howaru-Restore-Cropped2\" width=\"400\" height=\"130\"\/>\t\t\t\t\t<\/figure>\n\t<\/div>\n\t        <\/div>\n\t\n    <div class=\"c-block__body\" >\n\n\t\t\n\t\t\t\t\t<h3  class=\"c-block__title\">HOWARU\u00ae Restore<\/h3>\t\t\n\t    <div class=\"c-block__content\">\n\t\t    <div>\n\t\t\t\t\t\t\t    \n\t\t\t\t\t\t    <\/div>\n\t    <\/div>\n\n    <\/div>\n\n<\/article>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t<\/div>\n\n\t<\/div>\n\n\t\n<\/div>\n\n\n<div class=\"m-block  gt-l gb-l --bg-white --decor-blue --pattern-v4 --decor --stats-type2 txt-img-v2 l-content-2\"  >\n\n\t\n\t\n\t<div class=\"m-block__container container\" style=\"\">\n\n\t\t<div class=\"l-dcbl l-dcbl-v1\">\n\n\t\t\t\n<div class=\"c-block order-default\" style=\"--c-block-radius:0px; --c-block-gl: 0%;--c-block-gr: 0%;--c-block-gt: 0%;--c-block-gb: 0%;--columns-ratio: 50%;\">\n\t<div class=\"c-block__col c-block__text text-left align-center\" style=\"--c-txt-gl: 0%; --c-txt-gr: 0%; --c-txt-gt: 0%; --c-txt-gb: 0%;\">\n\t\t<div class=\"c-block__inner\">\n\t\t\t<div>\n\n\t\t\t\t\n\t\t\t\t    <div class=\"c-heading -h2\">\n\t\t\n\t\t\n\t\t\t\t\t<h2  class=\"c-heading__title\">Bl-04\u00ae CLINICAL STUDIES &#038; PUBLICATIONS\u200b<\/h2>\t\t\n\t\t\n\t\t    <\/div>\n\t<div class=\"c-heading__description is-wysiwyg\">\n\t\t\t\t\t<p>With more than 49 clinical trial publications, Bl-04\u00ae has also been studied in combination with other strains, not only in HOWARU\u00ae Protect Adult for immune support, but also as part of the HOWARU\u00ae Restore blend for digestive health.\u2075With more than 49 clinical trial publications, Bl-04\u00ae has also been studied in combination with other strains, not only in HOWARU\u00ae Protect Adult for immune support, but also as part of the HOWARU\u00ae Restore blend for digestive health.\u2075<\/p>\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\t<\/div>\n\n\t            \n\t\t\t<\/div>\n\n            \n\t\t\t\t\t<\/div>\n\t<\/div>\n\n\t<div class=\"c-block__col c-block__media\">\n\t\t\n\t\t\t<\/div>\n<\/div>\n\n\t\t<\/div>\n\n\t<\/div>\n\n\t\n<\/div>\n\n\n<div class=\"m-accordion  gt gb style-v2 l-two-cols\"  >\n\n\t\n\t\n\t<div class=\"m-accordion__container container\" style=\"\">\n\n        <div class=\"l-heading\">\n                <div class=\"c-heading -h2\">\n\t\t\n\t\t\n\t\t\t\t\t<h4  class=\"c-heading__title\">Health Benefit Areas<\/h4>\t\t\n\t\t\n\t\t    <\/div>\n\t<div class=\"c-heading__description is-wysiwyg\">\n\t\t\t\t\t<p>Each strain\u2019s health benefits are supported by recommended daily doses and peer-reviewed clinical studies.<\/p>\n<p><strong>Click on a Health Benefit to see more studies and learn more.<\/strong><\/p>\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\t<\/div>\n\t\t\t        <\/div>\n\n\t\t<div class=\"l-accordion l-accordion-v1 js-acc-wrapper icons-arrows\" style=\"--c-block-gl: 0px;--c-block-gr: 0px;--c-block-gt: 0px;--c-block-gb: 0px;\"  data-animation=\"js\">\n\n\t\t\t\n\t\t\t\t<div class=\"c-accordion c-accordion-v1\">\n\n\t\t\t\t\t\n                        \n\t\t\t\t\t\t\n<div class=\"c-accordion__item js-acc-item is-active\">\n\t\t\t\n\t\t<h3  class=\"c-accordion__title-wrap -h3\">\t\t<button class=\"js-acc-button c-accordion__title\">\n\t\t\t\n\t\t\t\n\t\t\tDigestive Health\u200b\t\t<\/button>\n\t\t<\/h3>\t\n\t<div class=\"js-acc-content\">\n\t\t\t\t\t\t\t<div class=\"c-accordion__content\">\n\t\t\t\t<div class=\"is-wysiwyg\">\n\t\t\t\t\t<div class='v1-column'>\n<ol>\n<li><strong>Supporting Daily Dose: <\/strong>17B (equal parts) 2B CFU Bl-04\u00ae\u200b<br \/>\n<strong>Study Reference: <\/strong><u><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24291194\/\" target=\"_blank\">Ouwehand AC, et al. Vaccine. 2014;32(4):458-463.<\/a><\/u><\/p>\n<li><strong>Supporting Daily Dose: <\/strong>10B CFU Total Bi-07\u00ae, Bl-04\u00ae, NCFM\u00ae, Lpc-37\u00ae\u200b<strong><br \/>\nStudy Reference: <\/strong><u><a href=\"https:\/\/www.mdpi.com\/2076-2607\/12\/4\/796\/\" target=\"_blank\">van Zanten G, et al. Microorganisms. 2024; 12(4),796.<\/a><\/u><\/li>\n<\/ol>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t    <div class=\"c-block__btn\">\n\t\t\n\t\t\t<a href=\"\/es\/health-sciences\/health-benefits\/digestive-health\/\"  class=\"c-btn -normal -primary has-icon icon-right\"><span class=\"c-btn__txt\">LEARN MORE<\/span><span class=\"c-btn__ico\"><svg width=\"30\" height=\"30\" class=\"icon icon-lib-icon-arrow1\" aria-hidden=\"true\" role=\"img\"><use xlink:href=\"#lib-icon-arrow1\"><\/use><\/svg><\/span><\/a>\n\t\t    <\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n<\/div>\n\n\t\t\t\t\t\t\n                        \n\t\t\t\t\t\t\n<div class=\"c-accordion__item js-acc-item\">\n\t\t\t\n\t\t<h3  class=\"c-accordion__title-wrap -h3\">\t\t<button class=\"js-acc-button c-accordion__title\">\n\t\t\t\n\t\t\t\n\t\t\tImmune Health\t\t<\/button>\n\t\t<\/h3>\t\n\t<div class=\"js-acc-content\">\n\t\t\t\t\t\t\t<div class=\"c-accordion__content\">\n\t\t\t\t<div class=\"is-wysiwyg\">\n\t\t\t\t\t<div class='v1-column'>\n<ol>\n<li><strong>Supporting Daily Dose: <\/strong>2B CFU Bl-04\u00ae\u200b<br \/>\n<strong>Study Reference: <\/strong><\/p>\n<ul>\n<li><u><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24268677\/\" target=\"_blank\">West N, et al. Clinical Nutrition. 2014;33(4):581-587.<\/a><\/u><\/li>\n<li><u><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28343401\/\" target=\"_blank\">Turner RB, et al. Benef Microbes. 2017;8(2):207-215.<\/a><\/u><\/li>\n<\/li>\n<\/ul>\n<li><strong>Supporting Daily Dose: <\/strong>1B CFU NCFM\u00ae, 3B CFU Bl-04\u00ae, 1 g FOS <strong><br \/>\nStudy Reference: <\/strong><u><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7753943\/\" target=\"_blank\">Bergmann K, et al. World Allergy Organ J. 2021;14(1):100494.<\/a><\/u><\/li>\n<\/ol>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t    <div class=\"c-block__btn\">\n\t\t\n\t\t\t<a href=\"\/es\/health-sciences\/health-benefits\/immune-health\/\" target=\"_blank\" class=\"c-btn -normal -primary has-icon icon-right\"><span class=\"c-btn__txt\">LEARN MORE<\/span><span class=\"c-btn__ico\"><svg width=\"30\" height=\"30\" class=\"icon icon-lib-icon-arrow1\" aria-hidden=\"true\" role=\"img\"><use xlink:href=\"#lib-icon-arrow1\"><\/use><\/svg><\/span><\/a>\n\t\t    <\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n<\/div>\n\n\t\t\t\t\t\t\n                        \n\t\t\t\t\t\t\n<div class=\"c-accordion__item js-acc-item\">\n\t\t\t\n\t\t<h3  class=\"c-accordion__title-wrap -h3\">\t\t<button class=\"js-acc-button c-accordion__title\">\n\t\t\t\n\t\t\t\n\t\t\tBeauty\t\t<\/button>\n\t\t<\/h3>\t\n\t<div class=\"js-acc-content\">\n\t\t\t\t\t\t\t<div class=\"c-accordion__content\">\n\t\t\t\t<div class=\"is-wysiwyg\">\n\t\t\t\t\t<div class='v1-column'>\n<p><strong>Supporting Daily Dose: <\/strong>1.75B CFU Bl-04\u00ae\u200b<br \/>\n<strong>Study Reference: <\/strong><u><a href=\"https:\/\/www.mdpi.com\/2673-6179\/2\/2\/5\" target=\"_blank\">Huuskonen L, et al. Dermato. 2022;2(2):30-52.<\/a><\/u><\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t    <div class=\"c-block__btn\">\n\t\t\n\t\t\t<a href=\"\/es\/health-sciences\/health-benefits\/beauty\/\" target=\"_blank\" class=\"c-btn -normal -primary has-icon icon-right\"><span class=\"c-btn__txt\">LEARN MORE<\/span><span class=\"c-btn__ico\"><svg width=\"30\" height=\"30\" class=\"icon icon-lib-icon-arrow1\" aria-hidden=\"true\" role=\"img\"><use xlink:href=\"#lib-icon-arrow1\"><\/use><\/svg><\/span><\/a>\n\t\t    <\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n<\/div>\n\n\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div class=\"m-banner m-banner--small banner-contact order-default\" >\n\n\t\n\t\n\t<div class=\"m-banner__container container-fluid\" style='--columns-ratio: 100%;'>\n\t\t<div class=\"m-banner__media\">\n\t\t\t<picture class=\"m-banner__picture\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1440\" height=\"810\" src=\"https:\/\/www.iff.com\/wp-content\/uploads\/2025\/06\/csm_IFF_Contact-Us_Signpost_ea7dc82dcc.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/www.iff.com\/wp-content\/uploads\/2025\/06\/csm_IFF_Contact-Us_Signpost_ea7dc82dcc.jpg 1440w, https:\/\/www.iff.com\/wp-content\/uploads\/2025\/06\/csm_IFF_Contact-Us_Signpost_ea7dc82dcc-300x169.jpg 300w, https:\/\/www.iff.com\/wp-content\/uploads\/2025\/06\/csm_IFF_Contact-Us_Signpost_ea7dc82dcc-1024x576.jpg 1024w, https:\/\/www.iff.com\/wp-content\/uploads\/2025\/06\/csm_IFF_Contact-Us_Signpost_ea7dc82dcc-768x432.jpg 768w, https:\/\/www.iff.com\/wp-content\/uploads\/2025\/06\/csm_IFF_Contact-Us_Signpost_ea7dc82dcc-400x225.jpg 400w, https:\/\/www.iff.com\/wp-content\/uploads\/2025\/06\/csm_IFF_Contact-Us_Signpost_ea7dc82dcc-200x113.jpg 200w\" sizes=\"auto, (max-width: 1440px) 100vw, 1440px\" \/>\t\t\t\t\t\t\t<\/picture>\n\t\t<\/div>\n\n\t\t<div class=\"m-banner__inner container flex-left style-dark\">\n\n\t\t\t<div class=\"l-banner  l-gt-d l-gb-d\" style=\"\">\n\n\t\t\t\t\n<div class=\"l-banner__text\">\n\t    <div class=\"l-banner__inner text-left\">\n\n        <div class=\"c-heading -h2\">\n\t\t\t\n\t\t\t\t\t\t\t<h2  class=\"c-heading__title\"> How Can We Help?<\/h2>\t\t\t\n\t\t\t        <\/div>\n\n\t\t            <div class=\"c-heading__description is-wysiwyg\">\n\t\t\t\t<p>We\u2019d love to talk to you about how our microbiome and bioscience expertise can help you develop, manufacture and deliver solutions that enable people at all life stages to live healthier and happier lives. \u200b<\/p>\n            <\/div>\n\t\t\t\t\n\t\t    <\/div>\n\t\t    <div class=\"c-block__btn\">\n\t\t\n\t\t\t<a href=\"\/es\/health-sciences\/contact-us\/\" target=\"_blank\" class=\"c-btn -normal -secondary has-icon icon-right\"><span class=\"c-btn__txt\">Contact Us<\/span><span class=\"c-btn__ico\"><svg width=\"30\" height=\"30\" class=\"icon icon-lib-icon-arrow1\" aria-hidden=\"true\" 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2.75825-2.44676-.03176-1.38986-1.05806-2.44728-2.72592-2.44728zm-2.488059 6.83477h4.874959v14.16473h-4.874994zm12.474729 2.05453s1.7633-2.3867 4.3933-2.3867c3.2071 0 5.6122 2.02465 5.6122 6.3755v8.1219h-4.8745v-7.5778c0-1.9042-.7056-3.2032-2.4696-3.2032-1.3468 0-2.1487.876-2.5013 1.7216-.1286.3028-.1605.7256-.1605 1.1491v7.9103h-4.87483v-14.16497h4.87523z\" fill=\"#99c8ec\" fill-rule=\"evenodd\"\/><\/svg><\/span><\/a>\n\t\t    <\/div>\n\t<\/div>\n\n\n\t\t\t<\/div>\n\n\t\t\t\t\t<\/div>\n\t<\/div>\n\n<\/div>","protected":false},"featured_media":34030,"template":"","product_health_benefits":[393,395,399],"product_type":[390],"class_list":["post-34029","our_products","type-our_products","status-publish","has-post-thumbnail","hentry","product_health_benefits-beauty","product_health_benefits-digestive","product_health_benefits-immune","product_type-probiotic-strain"],"acf":{"full_name":"HOWARU\u00ae Bl-04\u00ae \u200b","latin_name":"*Bifidobacterium lactis* Bl-04\u00ae","short_description":"HOWARU\u00ae Bl-04\u00ae modulates the immune system, improvement of overall skin health, and digestive health.\u200b","product_description":"<small><em>Image credits: \u00a9 IFF, Finland, 2021 (FESEM imaging VTT)<\/em><\/small>\r\n\r\nHOWARU\u00ae <em>Bifidobacterium lactis<\/em> Bl-04\u00ae, a human isolate long considered safe and suitable for human consumption, is well known for its excellent stability. Bl-04\u00ae has been thriving in a variety of foods and supplements for decades, and it has also been shown to survive passage through the human intestine.\u00b9,\u00b2 Bl-04\u00ae studies suggest it mechanistically modulates the immune system, and clinical data supports the use of this strain for immune health.\u00b3,\u2074\u200b","pdf_file":"","product_information":"<ul>\r\n \t<li>~66 preclinical studies<\/li>\r\n \t<li>~49 clinical publications<\/li>\r\n<\/ul>\r\n<img class=\"alignnone size-medium wp-image-24705\" src=\"https:\/\/www.iff.com\/wp-content\/uploads\/2025\/09\/HOWARU_VERIFY-Protocol-Quality-and-Safety_Logo-203x300-1.png\" alt=\"\" width=\"150\" height=\"300\" \/>","product_cfu":"","ingredients":"","regulations":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v28.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>HOWARU\u00ae Bl-04\u00ae for Immune &amp; Respiratory Health | IFF<\/title>\n<meta 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