{"id":34035,"date":"2025-07-07T07:17:00","date_gmt":"2025-09-10T03:33:39","guid":{"rendered":"https:\/\/www.iff.com\/health-sciences\/our-products\/howaru-b420\/"},"modified":"2026-03-06T11:15:52","modified_gmt":"2026-03-06T16:15:52","slug":"howaru-b420","status":"publish","type":"our_products","link":"https:\/\/www.iff.com\/es\/health-sciences\/our-products\/howaru-b420\/","title":{"rendered":"HOWARU\u00ae B420\u00ae"},"content":{"rendered":"<div class=\"m-banner m-banner--medium  mb theme-v1 layout-v1 cta-break-v1 order-default\" >\n\n\t\n\t\n\t<div class=\"m-banner__container container\" style='--columns-ratio: 40%;'>\n\n\t\t\n\t\t<div class=\"m-banner__inner container flex-left style-dark\">\n\n\t\t\t<div class=\"l-banner  l-gt-d l-gb-d\" style=\"\">\n\n\t\t\t\t\n<div class=\"l-banner__text\">\n\t    <div class=\"l-banner__inner text-left\">\n\n        <div class=\"c-heading -h2\">\n\t\t\t\n\t\t\t\t\t\t\t<h2  class=\"c-heading__title\">B420\u00ae BLEND\u200b<\/h2>\t\t\t\n\t\t\t                <div class=\"c-heading__sub\">HOWARU\u00ae Shape\u200b<\/div>\n\t\t\t        <\/div>\n\n\t\t            <div class=\"c-heading__description is-wysiwyg\">\n\t\t\t\t<p>B420\u00ae, also known as HOWARU\u00ae Shape, has demonstrated promise in both human clinical trials and animal studies in supporting weight management and inducing a better metabolic state.\u2075\u207b\u2077<\/p>\n            <\/div>\n\t\t\t\t\n\t\t    <\/div>\n\t\t    <div class=\"c-block__btn\">\n\t\t\n\t\t\t<a href=\"\/es\/health-sciences\/our-products\/howaru-shape\/\"  class=\"c-btn -normal -link has-icon icon-right\"><span class=\"c-btn__txt\">LEARN MORE<\/span><span class=\"c-btn__ico\"><svg width=\"30\" height=\"30\" class=\"icon icon-lib-icon-arrow1\" aria-hidden=\"true\" role=\"img\"><use xlink:href=\"#lib-icon-arrow1\"><\/use><\/svg><\/span><\/a>\n\t\t    <\/div>\n\t<\/div>\n\n\n\t\t\t<\/div>\n\n\t\t\t\t\t<\/div>\n\t<\/div>\n\n<\/div>\n\n\n<div class=\"m-block  gt-l gb-l --bg-white --decor-blue --pattern-v4 --decor --stats-type2 txt-img-v2 l-content-2\"  >\n\n\t\n\t\n\t<div class=\"m-block__container container\" style=\"\">\n\n\t\t<div class=\"l-dcbl l-dcbl-v1\">\n\n\t\t\t\n<div class=\"c-block order-default\" style=\"--c-block-radius:0px; --c-block-gl: 0%;--c-block-gr: 0%;--c-block-gt: 0%;--c-block-gb: 0%;--columns-ratio: 50%;\">\n\t<div class=\"c-block__col c-block__text text-left align-center\" style=\"--c-txt-gl: 0%; --c-txt-gr: 0%; --c-txt-gt: 0%; --c-txt-gb: 0%;\">\n\t\t<div class=\"c-block__inner\">\n\t\t\t<div>\n\n\t\t\t\t\n\t\t\t\t    <div class=\"c-heading -h2\">\n\t\t\n\t\t\n\t\t\t\t\t<h2  class=\"c-heading__title\">B420\u00ae CLINICAL STUDIES &#038; PUBLICATIONS\u200b<\/h2>\t\t\n\t\t\n\t\t    <\/div>\n\t<div class=\"c-heading__description is-wysiwyg\">\n\t\t\t\t\t<p><em>B. lactis <\/em>B420\u00ae has been documented in more than 90 scientific publications, including more than 30 clinical trial publications. It has been demonstrated in clinical trials to survive intestinal passage, and in vitro studies have shown excellent adhesion to human colonic mucus.\u2078\u207b\u00b9\u2070<\/p>\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\t<\/div>\n\n\t            \n\t\t\t<\/div>\n\n            \n\t\t\t\t\t<\/div>\n\t<\/div>\n\n\t<div class=\"c-block__col c-block__media\">\n\t\t\n\t\t\t<\/div>\n<\/div>\n\n\t\t<\/div>\n\n\t<\/div>\n\n\t\n<\/div>\n\n\n<div class=\"m-accordion  gt gb style-v2 l-two-cols\"  >\n\n\t\n\t\n\t<div class=\"m-accordion__container container\" style=\"\">\n\n        <div class=\"l-heading\">\n                <div class=\"c-heading -h2\">\n\t\t\n\t\t\n\t\t\t\t\t<h2  class=\"c-heading__title\">Health Benefit Areas<\/h2>\t\t\n\t\t\n\t\t    <\/div>\n\t<div class=\"c-heading__description is-wysiwyg\">\n\t\t\t\t\t<p>Each strain\u2019s health benefits are supported by recommended daily doses and peer-reviewed clinical studies.<\/p>\n<p><strong>Click on a Health Benefit to see more studies and learn more.<\/strong><\/p>\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\t<\/div>\n\t\t\t        <\/div>\n\n\t\t<div class=\"l-accordion l-accordion-v1 js-acc-wrapper icons-arrows\" style=\"--c-block-gl: 0px;--c-block-gr: 0px;--c-block-gt: 0px;--c-block-gb: 0px;\"  data-animation=\"js\">\n\n\t\t\t\n\t\t\t\t<div class=\"c-accordion c-accordion-v1\">\n\n\t\t\t\t\t\n                        \n\t\t\t\t\t\t\n<div class=\"c-accordion__item js-acc-item is-active\">\n\t\t\t\n\t\t<h3  class=\"c-accordion__title-wrap -h3\">\t\t<button class=\"js-acc-button c-accordion__title\">\n\t\t\t\n\t\t\t\n\t\t\tMetabolic Health\u200b\t\t<\/button>\n\t\t<\/h3>\t\n\t<div class=\"js-acc-content\">\n\t\t\t\t\t\t\t<div class=\"c-accordion__content\">\n\t\t\t\t<div class=\"is-wysiwyg\">\n\t\t\t\t\t<div class='v1-column'>\n<p><strong>Supporting Daily Dose: <\/strong>10B CFU B420\u00ae<\/p>\n<p><strong>Study Reference:<\/strong><\/p>\n<ul>\n<li><u><a href=\"http:\/\/ncbi.nlm.nih.gov\/pubmed\/27810310\" target=\"_blank\">Stenman LK, et al. EBioMedicine. 2016. Nov;13:190\u2013200.<\/a><\/u><\/li>\n<li><u><a href=\"https:\/\/www.ingentaconnect.com\/content\/wagac\/bm\/2019\/00000010\/00000002\/art00002\" target=\"_blank\">Hibberd A, et al. Beneficial Microbes. 2019. 10(2):121-135(15).<\/a><\/u><\/li>\n<\/ul>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t    <div class=\"c-block__btn\">\n\t\t\n\t\t\t<a href=\"\/es\/health-sciences\/health-benefits\/metabolic-health\/\" target=\"_blank\" class=\"c-btn -normal -primary has-icon icon-right\"><span class=\"c-btn__txt\">LEARN MORE<\/span><span class=\"c-btn__ico\"><svg width=\"30\" height=\"30\" class=\"icon icon-lib-icon-arrow1\" aria-hidden=\"true\" role=\"img\"><use xlink:href=\"#lib-icon-arrow1\"><\/use><\/svg><\/span><\/a>\n\t\t    <\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n<\/div>\n\n\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div class=\"m-block  gt gb l-content-simple-1\"  >\n\n\t\n\t\n\t<div class=\"m-block__container container\" style=\"\">\n\n\t\t<div class=\"l-heading text-left l-heading-v1\">\n\n\t\t\t<div class=\"l-heading__content\">\n\t\t\t\t\t<div class=\"c-heading__description is-wysiwyg\">\n\t\t\t\t\t<p><small><strong>References: 1. <\/strong>Lindfors K et al.; Clin Exp Immunol. 2008; <strong>2.<\/strong> Putaala H at al.; Res Microbiol. 2008; <strong>3.<\/strong> Mokkala K et al.; Nutr Res. 2016; <strong>4.<\/strong> Hibberd AA et al.; Beneficial Microbes. 2018; <strong>5. <\/strong>Stenman LK et al.; EBioMedicine. 2016; <strong>6.<\/strong> Stenman LK et al.; Diabetology &#038; Metabolic Syndrome. 2015; <strong>7.<\/strong> Stenman LK et al.; Beneficial Microbes. 2014; <strong>8. <\/strong>Klein A et al.; Eur J Clin Nutr. 2008;<strong> 9.<\/strong> Kok RG et al.; Appl Environ Microbiol. 1996; <strong>10.<\/strong> Collado MC et al.;Lett Appl Microbiol. 2007.\u200b<\/small><\/p>\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\n\t<\/div>\n\n\t\n<\/div>\n\n\n<div class=\"m-banner m-banner--small banner-contact order-default\" >\n\n\t\n\t\n\t<div class=\"m-banner__container container-fluid\" style='--columns-ratio: 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0-2.75783 1.05742-2.75783 2.44728 0 1.35918 1.05782 2.44676 2.69387 2.44676h.03163c1.70019 0 2.75825-1.08758 2.75825-2.44676-.03176-1.38986-1.05806-2.44728-2.72592-2.44728zm-2.488059 6.83477h4.874959v14.16473h-4.874994zm12.474729 2.05453s1.7633-2.3867 4.3933-2.3867c3.2071 0 5.6122 2.02465 5.6122 6.3755v8.1219h-4.8745v-7.5778c0-1.9042-.7056-3.2032-2.4696-3.2032-1.3468 0-2.1487.876-2.5013 1.7216-.1286.3028-.1605.7256-.1605 1.1491v7.9103h-4.87483v-14.16497h4.87523z\" fill=\"#99c8ec\" fill-rule=\"evenodd\"\/><\/svg><\/span><\/a>\n\t\t    <\/div>\n\t<\/div>\n\n\n\t\t\t<\/div>\n\n\t\t\t\t\t<\/div>\n\t<\/div>\n\n<\/div>","protected":false},"featured_media":34036,"template":"","product_health_benefits":[401],"product_type":[390],"class_list":["post-34035","our_products","type-our_products","status-publish","has-post-thumbnail","hentry","product_health_benefits-metabolic","product_type-probiotic-strain"],"acf":{"full_name":"HOWARU\u00ae B420\u00ae","latin_name":"\u200bHOWARU\u00ae *Bifidobacterium lactis* B420\u00ae","short_description":"\u200bThe primary health attributes of HOWARU\u00ae\u200b B420\u00ae are weight management and metabolic health.\u200b","product_description":"<small><em>Image credits: \u00a9 IFF, Finland, 2021 (FESEM imaging VTT)<\/em><\/small>\r\n\r\nThe primary health attributes of HOWARU\u00ae <em>Bifidobacterium lactis<\/em>\u200b B420\u00ae are weight management and metabolic health, which may be related to its ability to support intestinal barrier integrity.\u00b9\u207b\u00b3 In addition, <em>Akkermansia muciniphila<\/em>, a bacterial species linked to lean healthy body weight, was increased in abundance in the intestine upon B420\u00ae supplementation.\u2074 \u200b","pdf_file":"","product_information":"<ul>\r\n \t<li>90 scientific publications<\/li>\r\n \t<li>30+ clinical trial publications<\/li>\r\n<\/ul>\r\n<img class=\"alignnone size-medium wp-image-24705\" src=\"https:\/\/www.iff.com\/wp-content\/uploads\/2025\/09\/HOWARU_VERIFY-Protocol-Quality-and-Safety_Logo-203x300-1.png\" alt=\"\" width=\"150\" height=\"300\" \/>","product_cfu":"","ingredients":"","regulations":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v28.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>HOWARU\u00ae B420\u00ae for Weight &amp; Metabolic Health | IFF<\/title>\n<meta name=\"description\" content=\"HOWARU\u00ae B420\u00ae (Bifidobacterium lactis) is IFF\u2019s clinically studied probiotic strain shown to support healthy weight management and metabolic function.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iff.com\/es\/health-sciences\/our-products\/howaru-b420\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" 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