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HOWARU® Bl-04®​

HOWARU® Bl-04® ​

Bifidobacterium lactis Bl-04®

Image credits: © IFF, Finland, 2021 (FESEM imaging VTT)

HOWARU® Bifidobacterium lactis Bl-04®, a human isolate long considered safe and suitable for human consumption, is well known for its excellent stability. Bl-04® has been thriving in a variety of foods and supplements for decades, and it has also been shown to survive passage through the human intestine.¹,² Bl-04® studies suggest it mechanistically modulates the immune system, and clinical data supports the use of this strain for immune health.³,⁴​

Product Information:
  • ~66 preclinical studies
  • ~49 clinical publications

Health Benefits:
BeautyBeautyDigestive-HealthDigestiveImmune-HealthImmune

Bl-04®BLENDS

Learn more about IFF Health Sciences’ Bl-04® blends.

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HOWARU® GI Complete

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HOWARU® Protect Adult

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HOWARU® Restore

Bl-04® CLINICAL STUDIES & PUBLICATIONS​

With more than 49 clinical trial publications, Bl-04® has also been studied in combination with other strains, not only in HOWARU® Protect Adult for immune support, but also as part of the HOWARU® Restore blend for digestive health.⁵With more than 49 clinical trial publications, Bl-04® has also been studied in combination with other strains, not only in HOWARU® Protect Adult for immune support, but also as part of the HOWARU® Restore blend for digestive health.⁵

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Health Benefit Areas

Each strain’s health benefits are supported by recommended daily doses and peer-reviewed clinical studies.

Click on a Health Benefit to see more studies and learn more.

  1. Supporting Daily Dose: 17B (equal parts) 2B CFU Bl-04®​
    Study Reference: Ouwehand AC, et al. Vaccine. 2014;32(4):458-463.

  2. Supporting Daily Dose: 10B CFU Total Bi-07®, Bl-04®, NCFM®, Lpc-37®​
    Study Reference:     van Zanten G, et al. Microorganisms. 2024; 12(4),796.
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  1. Supporting Daily Dose: 2B CFU Bl-04®​
    Study Reference:

  2. Supporting Daily Dose: 1B CFU NCFM®, 3B CFU Bl-04®, 1 g FOS
    Study Reference:     Bergmann K, et al. World Allergy Organ J. 2021;14(1):100494.
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Supporting Daily Dose: 1.75B CFU Bl-04®​
Study Reference: Huuskonen L, et al. Dermato. 2022;2(2):30-52.

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